Top definition
the longing for something unattainable(could be a person or inhuman object) to the point of near insanity.

inspired by Edward cullen of the twilight seires
a: dude my girl wants to go all the way, but i took a vow of chastity

B: dude you've got some serious cullen syndrome
by Logan-943 May 15, 2009
Get the Cullen syndrome neck gaiter and mug.