Crusty and Ankles being compounded into one word.

Somebody with a unusual amount of crust on their ankles.

when you're hungover as shit after a spending a night drunk as a skunk

Crease left in your ankle by socks or tapered pants. Not to be confused with Cankles

Crankles: unusually skinny, bony ankles, which in comination with other observable traits, may indicate habitual use of methampetamine, also known as crank. A "crank skank", for example, would likely have crankles. Derived from the term "cankles" - its opposite.

The condition which usually afflicts large ladies where the ankle and calf are nearly the same diameter

A crack or pop of the ankle.

A person that gets inured easily, and constantly hurts themselves.