An expression used to accept a challenge, wage war or defend one's honor by unspecified but extreme/chaotic measures.
In all instances it is a simple way of indicating that come what may, your decision is set in stone.

when you're hungover as shit after a spending a night drunk as a skunk

An expression used to indicate anger, suprise, or frustration, and very often associated with a macro of Michaelangelo of the Teenage Mutant Ninja Turtles with a wide mouthed stare on his face.