1. The trade of goods between early Europe and the Americas that resulted in large cultural and material gains for European countries widespread disease in the unprepared American native tribes.
2. When a long term partner takes advantage of the other by not telling them about their herpes.
2. When a long term partner takes advantage of the other by not telling them about their herpes.
by Thorsbanjo September 13, 2011
The unfortunate situation when two groups of biddies that you have been hanging out with separably finally meet each other and the lines of communication open. Just like when Columbus found North America and the Western and Eastern hemisphere exchanged large amounts of communicable disease.
Hey man don't tell Shaniqua that we are going out tonight because Lashonda will be out too, we do not want another Columbian Exchange.
by thegregman April 26, 2012
by chillbrochill69 November 6, 2010
When two gay men engage in anal intercourse, and one comes inside the others anal passage and then procededs to suck the semen back out.
by I am J3sus December 3, 2006
Ej: That blowjob was awesome last night!
Lacy: If you didn't give me the columbian exchange, last night would've sucked!
Lacy: If you didn't give me the columbian exchange, last night would've sucked!
by Poppa Bear 69 March 25, 2014