When someone is acting like a proverbial uptight dick. Thinks he's funny when his sense of humor resembles a dried up 4 month old douche. Completely useless and, just like it's name sake, likely never going to end up in someone's mouth without being spat out and regretted instantly.

Also the male version of a cunt muffin or twat waffle.

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.