When someone is difficult, stubborn, hard headed, and whines or complains way too much about everything.

emotionally hardened; not feeling

The tough skin that commonly develops on the thumbs of videogamers, as a result of overuse of analog sticks.

Knobby build-up of dead tissue resulting from over-use in activities related to sex.
See also: Margaret's Pootie

When your entire toe becomes calloused. Untreatable and symtpoms may be elevated using foot polish.

The buildup of the lining of the throat from repeated deep throating resulting in the thickening and desensations of the throat enabling no holes barred cock gobbling

A statement of a derogatory or degrading manne which still maintains an element of humour, albeit perhaps not to the subject