Top definition
To practice and take part in the consumption of alcohol to further ones ability to consume larger and larger amounts of alcohol.

To strengthen your handle over your liquor.
Jay: "Tonight boys, we're building tolerance, I got the kegs an no ones leaving till we each black out"
Sean: "Cheers"
by OLES August 01, 2009
Get the mug
Get a Building Tolerance mug for your barber Riley.