When one womans breast is larger than the other.
Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome
by Chips and subs November 14, 2010
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A female consisting of a fat ass and no tits.
"Hey Ricky, dating that chick that has Biggy Smalls Syndrome will ultimately lead to your downfall."
by T.L. July 05, 2005
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