That could be either of the two biggest digits on your feet;
or when spelled thusly: Big T.O.E. refers to the Big Theory Of Everything, which by it self, is self explanatory.

Derived from the name 'Blackmore-Heal'; to have a large unlucky toe.

Someone who has an undeniably large big toe in comparison to the opposite toe, and other toes in the population of the world.

A cool person on the Perfect World International - Lost City server. He is a sexy veno.

When the big toe is used to penetrate the anus, and then you lick on the big toe.