When you get a wedgie so bad that it makes your balls hurt just like they tied in a knot.
Ron: "Dude, I just a major wedgie!"
Denny: "Man, that must have hurt like hell!?"
Ron: "Yah, I pretty much had my balls in a knot!"
by ManOfCars June 15, 2009
Get the Balls In A Knot mug.