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It means Hey You.
It is mainly used when addressing an individual in any given situation to get his or her attention.
Ayo! What time is it?
Ayo, Can I talk to you for a minute?
by E520 October 22, 2003
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Jul 3 Word of the Day
Your a Grillbilly when your grill is the nicest thing about your house.
You know your a Grillbilly when your house is falling apart and you have a beautiful stainless steel grill.
by hakkon218 February 02, 2010
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2
Just calling somebody out if you don't know their name.
Or expressing how dumb that action was.
Or telling people how cool the action or thing you're seeing is.
Ayo! Bring yo bitch ass here!

Ayo cmon dawg. that shit was dumb as fuck

AYOOOOOOO THAT SHIT WAS LIT ON THE DEAD HOMIES
by wowloserluffy September 24, 2020
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3
a streamlined fusion of the salutation "hey, yo" that goes over extremely well with the modern urban entrepreneur.
"ayo, slim, whatcha'll be on?"
by sinicalypse May 04, 2003
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4
a response for a very suspect or homosexual comment.
Dude 1: That's a big bulge in your pants, what is it?

Dude 2: AYOOOOOOO!!!!!!!!!!!!!
by Sosa Ave July 13, 2008
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6
This is a Nigerian name of the Yoruba dialect which means 'Joy'. It can be combined with other names.
e.g. Ayodele meaning Joy (Ayo) has come/arrived home (Dele)
by nun ur biznaess September 03, 2006
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