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It means Hey You.
It is mainly used when addressing an individual in any given situation to get his or her attention.
Ayo! What time is it?
Ayo, Can I talk to you for a minute?
by E520 October 22, 2003
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May 29 Word of the Day
Mercury retrograde is the act of taking a shit whilst mooning one or more human beings. Your day can typically being going well, according to your horoscope, until you are forced into witnessing Mercury retrograde. Performing Mercury retrograde will often speed the astrological cycle forward for the individual performing the Mercury retrograde, bringing about happy and fruitful times to come.
As the sun sank down over the pier, the children fishing gazed in horror as the lard-ass on his flat bottom boat sent the lakeshore into Mercury retrograde.
by BatWingg May 17, 2021
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2
a streamlined fusion of the salutation "hey, yo" that goes over extremely well with the modern urban entrepreneur.
"ayo, slim, whatcha'll be on?"
by sinicalypse May 04, 2003
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3
a response for a very suspect or homosexual comment.
Dude 1: That's a big bulge in your pants, what is it?

Dude 2: AYOOOOOOO!!!!!!!!!!!!!
by Sosa Ave July 13, 2008
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5
This is a Nigerian name of the Yoruba dialect which means 'Joy'. It can be combined with other names.
e.g. Ayodele meaning Joy (Ayo) has come/arrived home (Dele)
by nun ur biznaess September 03, 2006
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6
Someone everyone wants to be cause he's sick at everything
by Asssssssas November 07, 2016
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