When a show goes from being an awesome show online to a piece of shit on TV.
Fred used to be an okay show before it got movies on Nickelodeon. It's a victim of Annoying Orange Syndrome.
by MechanicalDoom June 21, 2014
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When an individual has absolutely no social skills and irritates people in their company with one stupid joke after another.
Dude, I can't stop making stupid puns. I think I suffer from annoying orange syndrome.
by I Love Ellie Elephant April 5, 2016
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