Exotic recreational drugs known by letter abbreviations, particularly in combination. Generally used as a derogatory term by people who do not partake in such things, and/or a descriptive term when everyone in a group of people at a party is on something different.

A concoction of multiple and many drugs that usually result in deadly overdoses that often take ones life.
Ex: "Mr. Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine," the office said in a short statement.
- CNN