1. The most common way to get AIDS/HIV. This is generally referred to as a booty call and involves Pitbull the rapper.

2. Shooting a ton of stupid no brain idiots in one night (generally used as zombies)
"I @#$@ Beyonce last night"
"Isn't that a one night stand?"
by Astupidwhiteboy September 25, 2017
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Hooking up with someone for one night of sex with no strings attached and hoping to never see them again. It is important not to exchange any personal info with them so they can't track you down and stalk you later.
I had a one night stand with this guy I picked up at the club.
by hidollarho February 25, 2004
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The act of having intercourse with a person but having no further relations to them after that.
"Nah man, it was only a one night stand, she was sexy though."
by acrobativity June 02, 2017
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Sexual activity with another person intended for one night only. (Derives from showbiz, a "one-off show". But also of course from the suggestion of a one-off erection, though the term is used by women as well as men as a candid description of "getting your rocks off" when a bit of no-strings fucking etc. was desired.
“I've never had a one-night stand because I've always been afraid that in the cold light of day, she'll wake up and think; "Oh my God! What the hell am I doing in bed with a stupid cunt like this?!”
by kofi May 14, 2003
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When you bang a chick with the intentions of never seeing or talking to her ever again.
by OmG July 19, 2003
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A One-Night Stand is where two consenting adults who are mutually horny agree to engage in coitus. One-Night Stands are only defined as such when the tryst lasts ONE night...no repeats! (otherwise we have casual sex). One-Nights Stands typically involve sprucing up, clubs/bars, copious amounts of liquor, great sex without small-talk, and driving away or leaving after sex.
Woman: "Want to head to my place?"
Man: "Sure, not looking for anything serious right now, just a One-Night Stand."
(great sex follows arriving at his/her place, girl or guy gets up to get dressed.)
Man/Woman: "Have a great night."
Man/Woman Reply: "You too."
(get in car and go home.)
by Medder89' December 29, 2011
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