The area code for cleveland. also known as a set or crew originating in the late eighties early nineties. This group is known for sticking together in numbers, and solving differences violently. Not your normal " street gang ". A family and group of friends from Cleveland who are proud of their city and heritage. Always making sure that others know who they are and where they are from. SOme of the 216 goes by the aliases Freak, Blue, Sluggo, Fatbak, Ghetto E, Greedo, and Gonzo.

When you eat dirt for the first time and leave your family to build a shack in the woods

Chapter in the manga, "Domestic na Kanojo". In this chapter there is a major breakup. Traumatizing for RuiXNat fans.

“216” classically pronounced “two-sixteen” is a name used amongst bro’s as reference to a bro piss, preferably while listening to NLE Choppa. 216’s are never meant to be turned down. Unless one bro just recently went on a 216, turning down a 216 is an outrage and a disgusting form of disrespect amongst bro’s.

It's the product of 6 x 6 x 6. A person who has this number tattooed on their person has identified themselves as an agent of change and rejects the status quo that has been set forth by religion.

a condition which causes a female to crave two "ones" in her "six", in which the "ones" represent fingers, while the "six" represents the vagina.
also, the act of putting two "ones" into someone's "six."