Acknowledgment that someone just did or said something stupid.

Usually said in a sarcastic and demeaning tone.
Mississippi resident: “Dude that shvelby (mullet) is tight he must pull all the fine bitches!”

Any one else: 2 4 It, F#&$ inbread idiot.

Other example

Seattle resident: I am going to put a definition on Urban Dictionary.

Friend: 2 4 It!
by Eno21 February 13, 2008
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When you get in trouble at Hyde School, you go "out to work" or on 2-4 where you spend all day doing manual labor and community service to "think" about what you made a mistake about. You get shit on by all faculty and are looked down upon by the head of school. Students in deans area "proctor" the students on 2-4 even if they are breaking ethics but just aren't getting caught. You have to sit at a different table than everyone, you can't talk to anyone, and you have these awful bootcamp workouts you have to do. And then you have a 3.5 hour "study hall" thats also proctored where kids dont do shit.
"Why you on 2-4?"
"I had brothers keeper on Eliza smoking a cig..."
by billy98798 November 29, 2012
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A Canadian slang term for Victoria Day. A day to celebrate Queen Victoria's birthday which was May 24th. Often done with fireworks and 2-4 (24 bottle) packs of beer.
"What are you doing for the May 2-4?"
"I'm having a huge party with fireworks and getting wasted!"
by HockeyRockNRollDude June 12, 2007
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*Recieving Plus +1 Free "TWOFORONE"

*Dual Personality Inhabiting Catalyst (think 'bout it...)

*The 6.5ft Behemoth of J.W.E. (jokers wild entertainment)

*Slaughterer of Horror-Core/HipHop, 241 has been butchering the ears and pupils of listeners around the midwest since Germs were Contageous.

*Like a Zombie Devouring the wasted brains of the rap game, IIIVI plagues the streets with a Sinister, Captivating, Morbid, afflicting sense of style that led him to become co-CEO of J.W.E.
"2-4-1 killed that performance & then reanimated it!"
by OrganDonorLoL October 16, 2011
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Giving a female two fingers in her pussy, and then backhanding her in the face.
"You better shutup now bitch, before i give ya the old 2-4!"
by the pupster September 06, 2007
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a variety of beer left over from previous parties that you combine into an empty beer box to make a 2-4. usually not the same beer in the box thats advertised on the box
"you want me to go pick up beer before the party tonight?"
"naw man its all good i can make a ghetto 2-4 with last weeks left overs "
by Nise06 December 30, 2007
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