SIS is an acronym popularized by the Canadian music artist Peaches in her song "Fuck The Pain Away" and it means "Stay in School".
Person 1: Remember the teachings of Peaches: "S-I-S, IUD, Stay in School 'cause it's the best"
Pesron 2: I love Peaches and, you know what, school is really the best!
Pesron 2: I love Peaches and, you know what, school is really the best!
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