Soul Sister 

The female equivalent of a blood brother. A best friend of the female persuasion that you consider family. Most times, the feeling is mutual.

Jackie and Rachel are soul sisters. It's like they have the same mother!

Soul Sister by wolfpacleader1986 October 10, 2010

Hey Soul Sister 

This single by Train gained popularity after headlining the compilation album "Now That's Who I Call a Bunch of Posing Prancing Cockmouths, Volume One."

If your date starts singing along to the opening buttfuck moans of Hey Soul Sister, shove her out of the car and run.

Hey Soul Sister by butttt June 13, 2010

soul sister 

boy or girl; someone of the opposite sex who you have everything in common with from music taste to birth defects. Even if you don't speak to this person frequently, when you do you can become like siblings within the hour.

Girl #1: "We have the same favorite song! Our parents have the same name! We both are allergic to Heinz Ketchup!"
Girl #2 "Why don't you marry him then?"

Girl #1: "I would, but we're already soul sisters!"

soul sister by truth goat June 4, 2014

soul sister 

A referent for a Black female. Since at least the early 2000s "soul sister" is usually shortened to sista without the word "soul". "Soul brother" brotha is the equivalent referent for a Black male.

1.Soul sister #9, sock it to me one more tme.

2. That soul sister knows she's lookin good.

soul sister by azizip17 December 26, 2011

Slay soul sister 

When your slay sister is a slay queen.

Slay sister 1: “SSSLAAAAYYYYYYYYYYY OMG SPILL THE TEEAAAAA”
Slay sister 2: “OMG SLAY SOUL SISTER”

Slay soul sister by Tea sister #1 March 13, 2023

Soul sister 

Women who engage in sexual intercourse at the same time with different people. Usually in different places, but to each their own.

She’s my soul sister, we were both hooking up with our exes last night.

Soul sister by Lee3443 January 7, 2022

soul sister 

a friend- or a group of friends -who is with you through thick and thin.

she is my soul sister.

soul sister by poopoo xx April 21, 2023