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PKU or Phenylketonuria is a rare genetic disorder in which the enzyme phenylalanine hydroxylase that converts phenylalanine (an amino acid in protein) into tyrosine does not work properly or at all. In this case the phenylalanine builds up in the blood stream and becomes toxic to the central nervous system. This can cause nerological complications like a lack of concentration, mood disorders, loss in IQ, memory loss, and sometimes severe mental retardation. There is no cure for PKU but the treatment includes low-protein diets and medical formula that gives you your lacking nutrients. PKU has been tested for at birth in the USA sine 1965.
I have a rare, inherited metabolic disorder called PKU.
PKU by pkugirl July 9, 2011
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#1

Mikey McFag: OMG GUYZ comment my new pics i took of myself in my bathroom with my iphone!

Carolyn: PKU

#2

Douchey Bus Driver: I DON'T BELIEVE IN SECOND CHANCES. SIT DOWN IN YOUR ASSIGNED SEATS.

Carolyn: PKU PKU PKU
PKU by ynamreGJa September 15, 2010
Related Words
PKU pkugcsq Pkunk
To kick another man in the balls, especially when its uncalled for.
"You got Pkunk'ed! Damn man that shit is whack!"
or
"You deserve to get a Pkunk for that dude!"
or
"Can you believe that shit!? She just went the Pkunk!"
Pkunk by Tazmanian May 15, 2007
pkugcsq
pkugcsq by SeijaKijin September 1, 2021
The grindset is a contemporary ideology of self-exploitation disguised as strength, deeply tied to the aesthetics of the “sigma male” and to new digital forms of patriarchy. It promotes the idea that human worth depends on productivity, economic success, absolute emotional control, and the ability to work endlessly, turning vulnerability, rest, community, and tenderness into signs of weakness. Beneath its rhetoric of discipline and power often lies a profound inability to relate healthily to pain, fragility, and human interdependence.
“That’s the grindset, brother. While weak men sleep and complain, sigma males stay disciplined, work in silence, suppress emotions, and build power while everyone else wastes time chasing comfort.”
Grindset by Omega-Male May 22, 2026
Word of the Day on May 23, 2026
well known from south park
rednecks get angrry that future folk took there jobs so they yell
They took ouare jerbs!
Them future folk took ouare jerbs!
jerb by Jimberley Kim April 7, 2005
Word of the Day on May 22, 2026
An Irish phrase meaning shit, derived from ass
(Not to be confused with the literal description of one's buttocks)
"Did you hear the song Aylek$ dropped?"
"Hardly. Her music is absolute cheeks."

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Cheeks by thecartisan April 26, 2020
Word of the Day on May 21, 2026