i.s.y.s. 

Intelligent
Sexy
Young (and)
Single

That girl is I.S.Y.S.

i.s.y.s. by Michelle68and1 August 23, 2006

I.S.S. 

A forum where the populace consists of 10-13 year olds. The website is basically a reject version of Niketalk. Users often debate on why their voice are changing, why little coils of hair are growing in private places, acne medication, a detailed step-to-step guide on how to kiss, the "birds and the bees" talk, official what elementary school do you go to post, how to convince parents to buy $300 pair of shoes, and etc.

Here is a compilation of the "characters" on I.S.S.:
1. LatinFusion aka Bobblehead, No Neck, or Emo Spic
2. Shortyrockjayz aka Never Walked , Snorlaxrockjayz, Smelly Fat Pussy, or All My Jordans Never Crease Cuz My Feet Provides The Stuffing (Basically she is fat as shit.)
3. b ! o h a z R D aka AzN fAgGoT.
4. That Spanish girl who wears her glasses to the tip of her nose (Poser)
5. Too many Asian "gangsters" to note. (irocknikes)
6. iCEDOUTNiKZ aka Proactiv/Slim Fast model.

Some popular quotes frequently used on the forum:

1. "THOSE ARE SOME HOT FLINT XIIIS!"
2. "DAMN NICE OUTFITZ! WHERE CAN I COP THE WHOLE THING?"
3. *female posts an image of what she's wearing but the head is not present* "OMFG UR SO FUKIN HOT!"
4. "YEAH I'LL FUCK YOU UP! COME MEET ME AT X TOMORROW" - Scrawny 12 year old.

I use my mommy's grocery money to buy my Jordans. (I.S.S.)

I.S.S. by Nelson C January 2, 2006

I.S.T 

"The International School of Tanganyika" is located in Dar es Salaam,Tanzania and is probably the worst school ever built. It's mostly populated by (in no racist way what so ever) racist Arab guys who like to mess around with people until you hit them back,launching you into what they like to call "beef" with all the other school Arabs. They drive around in their ugly ass rav 4's and tricked out mitsubishi's at night trying to act all gangster. See K-Unit

-Hey dude where do you go to school?
-I.S.T man.
-WHOA. I'm sorrry man.

I.S.T by B-E-A-N-S-I-E October 6, 2008

I.S. 227 

Bummy ass school with racists ass teachers. Ppl are always fighting and someone is always in trouble. People have sex under the stair case, smoke/vape, sell drugs, etc. horrible ass skl

I.S. 227 is ass

I.S. 227 by kdadonn March 26, 2023

I.S.I.W.Y.A.I.H.Y.K. 

I'm so inlove with you and I hope you know.

send mo sa crush mo to (I.S.I.W.Y.A.I.H.Y.K.) pag nahihiya kang umamin.

I.S.I.W.Y.A.I.H.Y.K. by love_u_Jhay August 25, 2021

I.S.H

An Acronym for "If Shit Happens"

".I.S.H We still have plan B"

I.S.H by Paddy O'Mally May 15, 2008

I.S.M. 

An Italian Sandwich Model. Its a line of work that most people are just not cut out for, but become one, and you'll basically be living the dream.

While "Runway" Models might frown upon this profession in the public eye, deep down inside they just know they're not cut out for the job and are uber-jealous.

Italian, Sandwich, Model, Living the Dream, Its not a big deal, Way of life, I.S.M.

"Oh so you work at your parents pizza shop, you know what you look like, an Italian Sandwich Model"

I.S.M. by Witzy Pop October 25, 2011