Dregma Share definition Flag A combination of the words 'Dreg' & 'Smegma' meaning the lowest of the low, a bad smell, situation or stagnant drink. Nah, its just warm dregma at the bottom. Dregma by Sketchmere June 3, 2011 0 0 Get merch Get the Dregma mug. Buy Now — $32.95 See more merch