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Standing for Pre-Fap-Stress-Disorder.. Refers to when a person usually male feels the extreme need or desire to masturbate.
ex.

Guy 1: hey man why were you acting like that earlier?

Guy 2: sorry dude i had a bad case of PFSD. I used your bathroom to correct the problem.
PFSD by themetal02 August 10, 2012
Related Words
pfs PFSD pfSense Pfsanea pfsh pfshtz PFSISTCBISACPDAY PFSL PFSNL PFSOP
Derived from packet-filtering tool, pfSense is known to be "The world's most trusted open-source firewall," often used by people who want a kick-ass feature-full router, or just want to get into more advanced networking.
John: "Why the hell is David using pfSense for his home router?"

Lucas: "I don't know, he probably wants flexible home network with alot of features."
pfSense by It's not snowing January 16, 2018
Post Football Season Depression

A condition one suffers after the Superbowl. This condition usually last until August. It may also force one to watch sports they would not normally watch. There is no known cure, but alcohol has been known to make the symptoms tolerable.
Hey man what's with the bowling? I am suffering form PFSD man..looks like I will have it until at least August...
PFSD by tmgwhodat February 8, 2010
Pres Friday, Sesh Saturday

A synonym devised from one of the core group founders of the sesh PFSS were the first group of alpha males to devote their weekends to the boys.

Always remember, a VK or two will never hurt.
i want to sesh like the PFSS
PFSS by Big Bey Niccy Dunc February 28, 2019
Post-Feminism Stress Disorder; a severe mental condition which most commonly affects conservatives against the teachings of modern feminism and its effects on society
My girlfriend is being a feminist bitch and getting upset over every little thing. She's never satisfied and wants to break up with me over something that's her fault. I hate feminism. It's driving me crazy. I think I might have PFSD.
PFSD by bambitheslug December 27, 2011
Meaning weak rubbish and used predominantly by emos and the sci-fi computer gaming community in response to statement or question you disagree with to imply the same. Entered the lexcon via my space/faceparty and similar social e-networking sites.
example 1 - Conversation on an internet forum relating to anime characters from the Final Fantasy 7 plysation game.

- Sepiroth's cute
- pfsssh look at Seph he looks like a demented clown without make-up

- But you're blond, all the guys like you
- pfsssh being blonde doesn't mean anything!!! i was actually thinking of going back again..=\
pfsssh by Samantha Welch December 27, 2008