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G's up, Ho's down 

This comes from the streets, man! Often referred to in rap songs. It indicates the need to have the gangsters "up" or on top of things, and keep the Ho's (bitches) down. Thought to have originated from pimps who would say it to indicate their whores were on their backs making the money for the pimps. Often said when greeting a fellow G, or upon entering a room or party. Meant to re-assure
G1: Greetings. G's up, ho's down.
G2: Fo' shizzle, ma' nizzle. Word.
G's up, Ho's down by Gacis June 2, 2004

G's up, Ho's down 

Bangin ass ecstasy pills
popular in jersey
u got sum G's up, Ho's down ma nigga?
G's up, Ho's down by munx March 30, 2007

G's up, Ho's down 

Ecstasy pills with the letter G with a dot on one side and a chick on the other. If you in Jersey and got this be aware that it is most likely MDA, not MDMA. Check MDA out on erowid and check ecstacyinfo.org (search for "g" and you'll see and entry for Newark, NJ which says it was tested positive for MDA).
"The dance is Saturday and I just got hooked up with some G's up, ho's down."

G's up, Ho's down  

G's up, hoes down, while you motherfuckers bounce to this

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G's up, Ho's down

Pimps Up, Ho's Down

A pair of imperative commands to be issued during a school lockdown or other mandatory activity involving hiding on the floor. Intended to trap others in the dilemma of either standing up and risking their safety (as pimps would) or staying down and safe while unfortunately implying that they are hoes. More grammatical immediately after a ho has been brought down by tripping, choking, heart attack, drive-by shooting, etc. Also the title of a classic 1999 film chronicling eight American pimps' pimping.
1. School principal: (over PA system) "A suicidal man has been spotted outside school grounds. We ask that teachers initiate standard lockdown procedures."
Teacher: "Okay, I need some of you to sit on the floor along this wall, and--
Aaron: (springing out of school desk seat) "PIMPS UP, HOES DOWN!"
Other students: (to selves) Damn! I might as well find myself a street corner on 8 Mile!
(Aaron dons purple felt hat, crosses arms)

2. (A girl slips and falls on the wet hallway floor)
Aaron: (donning purple felt hat) "PIMPS UP, HO'S DOWN!"
Ho: (getting up) "Asshole."

3. Aaron: "PIMPS UP, HO'S DOWN!"
Ho: (still standing) "That movie's title is punctuated poorly."
Aaron: "GET DOWN HO wait wha-- . . . ?" (Uneasily fingers pimp hat)

G's up, Ho's down 

Created by G-Unit member lil scrappy. The letter "G" stands for gorilla. It means that the gorillas should be on top and their bitches (hoes) must bend over or something like that...
G's up, Ho's down=
G's stand up so that the ho's can do their job.
G's up, Ho's down by dudler January 10, 2008