Is often a compliment to the human, has a very nice impact on your life when used. Downie is a word that defines a person, who looks the same as every other downie and look Asian. Has very destinct jawbone structure and can manipulate you into engaging with sexual activites without your knowledge. Be aware of the Downie.
Person 1: Wow, you are such a downie!
Person 2: Aw, thank you man! That means alot to me!
Down syndrome, also known as trisomy 21, is a disease with a connection between mental disability and physical malformation. A downie is a person with this condition.
Marco is a boy who was born with down syndrome. He is going to a special school with other downies.