IFRD otherwise known as insanely fucking retarded disorder. You would use to ask your friend if they have IFRD and listen to them be confused about it.
F: dude what the fuck is wrong with you, do you have IFRD
N: what is IFRD I dont what that is
IFSD otherwise known as insanely fucking sexy disorder. You would use this on a girl or guy and either tell them what it means or not it's your choice
G: you see that girl ima go ask her if she has IFSD
B: go on bro I dare you to tell her what it means to