Something you obsess over to the point that it nearly or completely destroys you. An obsession that becomes your ultimate goal in life; one that your life now completely encircles and defines you.
Captain Ahab was so obsessed with killing Moby Dick (the white whale) that it in turn killed him.
The desire to be thin became her white whale. Through diet pills, starvation, vomiting, and obsessive exercise, she was determined to be skinny.
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