A portmanteau word built from the words skank and cunt, usually used to describe or deride any undesirable, bitchy, vile, or opprobrious female. Of course, the word also carries with it an allegation (founded or unfounded) of loose morals and a generally dubious sexual comportment by the individual at whom the insult is directed. Synonyms include: bitch, slut, wench, slapper, ho-bag, etc.
My ex-boss was the biggest skunt imaginable.
John: Holy shit, man. Get a load of this chick that just walked in.
Jack: Eh, she's got a nice rack, but she looks like a total skunt.
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