When Oprah withdraws support for your book. It can also mean when Oprah doesn't give or withdraws support for anything.
Etymology: Used on E! Channel's "The Soup" on March 3, 2006 in the "Hollywords" segment. It was in reference to Oprah's withdrawal of support for James Frey's memoir "A Million Little Pieces" after it was revealed that his story was grossly exaggerated and (in parts) fictional.
Getting the noprah automatically ruins your career as a writer. No one crosses Oprah. No one!
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