It basically describes the nice guy. A guy who will listen to his female friend's every complaint, rant, problem, and experience in life; will help them out no matter to the cost to them; would die for their friends without even thinking; but can never get a girlfriend. All their female friends will continue to go out with mindless, stupid assholes that treat them like shit, and hurt them over and over again, never even considering the nice guy, because of his "normal" physical appearance.
Guy 1: Hey, Joe, why don't you have a girlfriend?
Joe: I really can't - I've got nice guy syndrome."
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