to entertain the advances of an unattractive, beastly woman, usually at a bar or club. Often influenced by the later hours of the night when beer goggles are in full effect. Also usually followed by a buddy coming in to save you by whatever means necessary. The phrase is rooted in a popular national Beef Jerky commercial.
"Look at Brent over there at the bar! He's messin with sasquatch! somebody go save him!"
"Dude, who was that hideous girl you were talking to last night?"
"I don't know man, whenever I drink to much I always end up messin' with sasquatch"
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