1. the most important
2. a favorite girlfriend or boyfriend
3. a best friend, usually a dude, as in "my main man".
4. ebonics for "man"
5. main vein, the vein used to inject heroin, see also main lining
1. "if you're going to snort it, you might as well pop it, and if you're going to shoot it, you might as well main it" (from basketball diaries by jim carroll)
2. "that's my main girl"
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