A command for someone to get lost (especially from the person that says it), usually as a result of extreme annoyance. Literally it means for them to masturbate themselves, so they aren't inclined to harrass and receive sexual pleasure from the person they are annoying. It's more stinging than "fuck off" because it implies that they could not or should not find anyone else to have sex with, so they need to use the self-manipulation.
"lol, looks like i beat you at WoW again..." "go fuck yourself"
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