1. Chess. an opening in which a player seeks to obtain some advantage by sacrificing a pawn or piece.
2. any maneuver by which one seeks to gain an advantage.
"Man, I thought you had him when you were picking off all his guys, but he was just running a gambit on your ass."
"O.K., we're loosing this battle, unless we do something quick we're all going to be killed. We need to run a gambit on them. Half of us are going to flank thier rear."
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