1. A polite and well meaning colloquialism. This phrase gained popularity when famed rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy."
2. To informally aquiesce or agree with someone whom you consider an affable peer.
My friend Tim was like, "Whassup Dog, are you going to the game tonight?" I responded "Fo' Shizzle my nizzle" in the pitch of a tenor.
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