When a person is so fat that where their knuckles (the ones that join the finger to the hand) dips down. This is caused by having an excess of fat on the hand that extends over the knuckle bone causing a dip where the knuckle is located.
Person 1: Fat people are gross.
Person 2: Yeah, she thinks her fat isn't noticeable under all that baggy clothing, too bad she has fat knuckles.
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