As used in eastern Carteret County in NC, it is an interjection indicating extreme doubt or incredulous disbelief.....due to the Down East dialect, it is often pronounced "droim"....(note: it is NOT an expression of dismay as another poster has stated)
You caught 50 boxes of flounder last week? Drime, I reckon you did!
For an EXTREME expression of disbelief, it is sometimes followed with "down"
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