named after the behavior in which a coyote will sometimes chew off its own leg when the leg has become caught in a trap. In people, the ”Coyote Syndrome” refers to when a person wakes up the morning after a one night stand to find the person their arm is around is butt-ugly without the beer goggles (after drinking alot ugly people start to look attractive) they had on last night, so they'd rather chew off their own arm than wake the ugly person up.
Guy: Man, i drank wayyy to much last night! I suffered coyote syndrome when i woke up next to that girl I went home with.
Friend: Damn that sucks, and yeah she was pretty fugly.
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