This word has no inherent meaning but can be used in place of any word (sort of like fuck or smurf: smurf-berries, have a smurfy day, etc).
Chuckle is usually taken to mean the most perverse, obscene, or disgusting thing imaginable in the given context.
Chuckle me tenderly.
I chuckled up a storm in the bathroom.
I want to chuckle that waitress.
Oops, I chuckled myself.
Chuckle my wompus!
Are you the Chuckler?
Dude, it was chuckle central at that party.
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