Originally in reference to feeding an opium addiction, this can refer to ploughing through any task past the point of diminishing returns, with disregard to one's own health, sanity or well-being.
We shot 16 hours yesterday, so rather than go to sleep, I had a couple espressos and followed it with a handful of vivarin to work through the night. It's 9:00 AM and by this point, I'm just chasing the dragon.
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