To completely dumbfound, confuse, or otherwise render speechless by either asking a question or stating something beyond their intelligence.
Toni:The mechanism of endocannabinoid synaptic transmission is believed to occur as follows: first, transmission of the excitatory neurotransmitter glutamate causes an influx of calcium ions into the post-synaptic neuron.
Guy: ummm... what? (Toni baffled Guy)
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