"Runs" usually refers to diarrhea. The term runs is derived by three different events that accompany diarrhea. (The three runs).
1. You run to the bathroom.
2. You sit down and the shit runs out of you at a surprising velocity.
3. You run out of toilet paper because you have to wipe your ass so much.
Wow, Jerry sure went to the bathroom in a hurry, he must have the runs.
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