A meme-level expression used in response to anything sexually pleasing/enticing, whether it is an image, video, song, or written content.
It is most commonly used as a simple image macro featuring George Takei; the meme itself probably originated from instances of Takei saying "Oh, my!" in response to sexy stuff, especially on the Howard Stern show.
Howard Stern: Hey Jonah, let's see that gigantic penis of yours.
Jonah Falcon: K. *whips out 13-incher.*
George Takei: Oh my! :
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