Behaviour outside the realms of normal, with respect to the individual.
To do one's own thing.
To 'give the birdie' to the world and make a concerted effort to annoy / piss off / offend as many people as possible in a given timeframe.
John: Er... is Calvin off on one?
James: Nope - he usually chases pigeons on his lunchbreak.
James: Woah - does Miranda usually dance on tables whilst inebriated, sans underwear??
John: Nope - she's off on one.
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