A hook-up that is so intense, it's of nuclear proportions.
Variations: Nuke it out; Nukin'
Caking, smashing, nailing, boning, etc. all have similar meanings, but none can match the intensity level associated with "nuking."
Paul: "Bro, did you ever end up gettin' with that bitch last night?"
Dan: "Dude. We nuked it out for the longest time, it was unbelievable. I'm gonna try and nuke her again later tonight..."
Paul: "Shit, man...I saw you guys cakin' it but I didn't think you'd actually nuke her."
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