When something becomes so confusing or intertwined with something else that it causes massive confusion in a person. Similar to a roofie being slipped to someone, causing confusion and a feeling that you were just fucked (or in this case, Mind-Fucked).
Man 1: I just saw that Leo Dicaprio movie "Inception" last night and I have never felt this weird feeling before...
Man 2: I think the word you're looking for is "Mind-Fucked".
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