Referring to My Little Pony - Friendship is Magic
The Mane 6 are the 6 main characters of this show, however the wordgame with "mane" has been evidently created by the Bronies, see Brony.
Their names: Twilight Sparkle, Rainbow Dash, Rarity, Applejack, Pinkie Pie, Fluttershy.
Brony 1: Hey, who's your favourite of the Mane 6?
Brony 2: Pinkie Pie, of course!
Brony 3: Well, mine's Rainbow Dash.
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