Stands for Mother Sister Black. A woman that is african-american, has children and is known to a guy as his buddy's sister would classify as an MSB. Most white men have an 'achivement sex list' which includes a mom, a black girl, somebody's sister, a teacher, etc... If a white guy has sex with an MSB it is considered a powerful achievement.
Duder 1: "I can't believe you fucked Garrett's sister. She's half black and has a kid dude. You totally scored an MSB!"
Duder 2: "I know man, it was pretty amazing. Those titties were so nice."
Duder 1: "Damn! You're so far ahead of me now. All you have left on your list is a teacher. I got a lot of catching up to do."
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