Can be used as an exclamation, a question, or an answer to any question. However, it can only be used by short Italian guys that have low voices, a "New York" accent and are built to rip a car in half. They are usually named Vinny. If anyone else were to use it, someone that DOES qualify will surely be in earshot and would immediately appear and start "trowin' a beatin' on ya!
See a cute girl: "Fuck Bro", hit thumb with hammer: "Fuck Bro", ask: Do you want fries with that: "Fuck Bro", I just won a million dollars!!: "Fuck Bro?"
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