To get your ass kicked REALLY badly. If you got "duffed", you didn't just get punched in the face, hit the floor and kicked once or twice hard... you got hit in the face, hit the ground, then got hit in the face several more times, possibly had your head bashed into the cement, got kicked in the ears, neck, kidneys and various other soft spots on your body.
"Yung, that nigga D-Set laid up in the hospital. He smoked up that whole QP he was fronted by main man and got duffed."
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